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GORASP2

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GENERAL INFORMATION

Gene name

 GORASP2

Gene description

 Golgi reassembly stacking protein 2, 55kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA035274 , HPA035275
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ASSAYS
RNA expression
Human cells
Custom data
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus.

Main location

 Golgi apparatus (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035274 A-431 Golgi apparatus
HPA035274 U-2 OS Golgi apparatus
HPA035274 U-251 MG Golgi apparatus
HPA035275 A-431 Golgi apparatus
HPA035275 U-2 OS Golgi apparatus
HPA035275 U-251 MG Golgi apparatus

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA035274 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. GORASP2 localizes to the Golgi apparatus and is partly detected in the cis-Golgi compartment and other Golgi compartments.

siRNA VALIDATION

Antibody

 HPA035275

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Cytoplasmic region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 27%55%

p-value

 < 0.01< 0.01
 

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Sample

Cell line
HPA035275 siRNA 1 U-2 OS
HPA035275 siRNA 2 U-2 OS
HPA035275 scrambled U-2 OS

GENE INFORMATION

Gene name

 GORASP2 (HGNC Symbol)

Synonyms

 GOLPH6, GRASP55, GRS2

Description

 Golgi reassembly stacking protein 2, 55kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 170928464 - 170967129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115806 (version 83.38)

Entrez gene

 26003

UniProt

 Q9H8Y8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H8Y8

Antibodypedia

 GORASP2 antibodies

PROTEIN BROWSER
GORASP2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GORASP2-001
ENSP00000234160
ENST00000234160
Q9H8Y8 [Direct mapping]
Golgi reassembly-stacking protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0006996 [organelle organization]
GO:0016020 [membrane]
Show all
 452 aa
47.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.