Expression of GORASP2 in cancer - Summary

GENERAL INFORMATION
Gene name	GORASP2
Gene description	Golgi reassembly stacking protein 2, 55kDa
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and cell membranous expression in several tissues, mainly in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression.
Reliability score	Supported based on 2 antibodies. HPA035274 , HPA035275
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035274	HPA035275

GENE INFORMATION
Gene name	GORASP2 (HGNC Symbol)
Synonyms	GOLPH6, GRASP55, GRS2
Description	Golgi reassembly stacking protein 2, 55kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	170928464 - 170967129
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115806 (version 83.38)
Entrez gene	26003
UniProt	Q9H8Y8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8Y8
Antibodypedia	GORASP2 antibodies

PROTEIN BROWSER

GORASP2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GORASP2-001 ENSP00000234160 ENST00000234160	Q9H8Y8 [Direct mapping] Golgi reassembly-stacking protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006996 [organelle organization] GO:0016020 [membrane] Show all	452 aa 47.1 kDa	No	0