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CDCA8

GENERAL INFORMATION

Gene name

 CDCA8

Gene description

 Cell division cycle associated 8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in dividing cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA028120 , HPA028258 , HPA028783
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), melanoma (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Melanoma p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA028120
HPA028258
HPA028783

GENE INFORMATION

Gene name

 CDCA8 (HGNC Symbol)

Synonyms

 BOR, DasraB, FLJ12042, MESRGP

Description

 Cell division cycle associated 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 37692418 - 37709719

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134690 (version 83.38)

Entrez gene

 55143

UniProt

 Q53HL2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q53HL2

Antibodypedia

 CDCA8 antibodies

PROTEIN BROWSER
CDCA8-001
CDCA8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDCA8-001
ENSP00000362146
ENST00000373055
Q53HL2 [Direct mapping]
Borealin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010369 [chromocenter]
GO:0030496 [midbody]
GO:0032133 [chromosome passenger complex]
GO:0043234 [protein complex]
GO:0045171 [intercellular bridge]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
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 280 aa
31.3 kDa 		No 0
CDCA8-002
ENSP00000316121
ENST00000327331
Q53HL2 [Direct mapping]
Borealin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030496 [midbody]
GO:0032133 [chromosome passenger complex]
GO:0043234 [protein complex]
GO:0045171 [intercellular bridge]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
Show all
 280 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.