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CDCA8

GENERAL INFORMATION

Gene name

 CDCA8

Gene description

 Cell division cycle associated 8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in dividing cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA028120 , HPA028258 , HPA028783
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 CDCA8 (HGNC Symbol)

Synonyms

 BOR, DasraB, FLJ12042, MESRGP

Description

 Cell division cycle associated 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 37692418 - 37709719

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134690 (version 83.38)

Entrez gene

 55143

UniProt

 Q53HL2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q53HL2

Antibodypedia

 CDCA8 antibodies

PROTEIN BROWSER
CDCA8-001
CDCA8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDCA8-001
ENSP00000362146
ENST00000373055
Q53HL2 [Direct mapping]
Borealin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010369 [chromocenter]
GO:0030496 [midbody]
GO:0032133 [chromosome passenger complex]
GO:0043234 [protein complex]
GO:0045171 [intercellular bridge]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
Show all
 280 aa
31.3 kDa 		No 0
CDCA8-002
ENSP00000316121
ENST00000327331
Q53HL2 [Direct mapping]
Borealin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030496 [midbody]
GO:0032133 [chromosome passenger complex]
GO:0043234 [protein complex]
GO:0045171 [intercellular bridge]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
Show all
 280 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.