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CDCA8

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GENERAL INFORMATION

Gene name

 CDCA8

Gene description

 Cell division cycle associated 8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli & cytokinetic bridge.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (validated), Cytokinetic bridge (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA028120 , CAB040294
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli & cytokinetic bridge.

Main location

 Nucleoli (validated), Cytokinetic bridge (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA028120 A-431 Nucleus Intensity
Nucleoli Intensity
HPA028120 U-2 OS Nucleus Intensity
Nucleoli Intensity
Cytokinetic bridge Intensity Intensity
HPA028120 U-251 MG Nucleus
Nucleoli Intensity
Nuclear bodies
CAB040294 A-431 Nucleoli
CAB040294 U-2 OS Nucleoli
Cytokinetic bridge Intensity Intensity
CAB040294 U-251 MG Nucleoli

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Cytokinetic bridge, Nucleoli

GENE INFORMATION

Gene name

 CDCA8 (HGNC Symbol)

Synonyms

 BOR, DasraB, FLJ12042, MESRGP

Description

 Cell division cycle associated 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 37692418 - 37709719

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134690 (version 83.38)

Entrez gene

 55143

UniProt

 Q53HL2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q53HL2

Antibodypedia

 CDCA8 antibodies

PROTEIN BROWSER
CDCA8-001
CDCA8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDCA8-001
ENSP00000362146
ENST00000373055
Q53HL2 [Direct mapping]
Borealin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010369 [chromocenter]
GO:0030496 [midbody]
GO:0032133 [chromosome passenger complex]
GO:0043234 [protein complex]
GO:0045171 [intercellular bridge]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
Show all
 280 aa
31.3 kDa 		No 0
CDCA8-002
ENSP00000316121
ENST00000327331
Q53HL2 [Direct mapping]
Borealin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030496 [midbody]
GO:0032133 [chromosome passenger complex]
GO:0043234 [protein complex]
GO:0045171 [intercellular bridge]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
Show all
 280 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.