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Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
P63000 [Direct mapping] Ras-related C3 botulinum toxin substrate 1 A4D2P1 [Target identity:100%; Query identity:100%] Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_a; Ras-related C3 botulinum toxin substrate 1 isoform Rac1; cDNA FLJ30431 fis, clone BRACE2008968, highly similar to Ras-related C3 botulinum toxin substrate 1; cDNA FLJ75553, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA
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Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008361 [regulation of cell size] GO:0009611 [response to wounding] GO:0009653 [anatomical structure morphogenesis] GO:0010310 [regulation of hydrogen peroxide metabolic process] GO:0010592 [positive regulation of lamellipodium assembly] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0030027 [lamellipodium] GO:0030032 [lamellipodium assembly] GO:0030036 [actin cytoskeleton organization] GO:0030041 [actin filament polymerization] GO:0030168 [platelet activation] GO:0030334 [regulation of cell migration] GO:0031295 [T cell costimulation] GO:0031529 [ruffle organization] GO:0031996 [thioesterase binding] GO:0032707 [negative regulation of interleukin-23 production] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042470 [melanosome] GO:0043065 [positive regulation of apoptotic process] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048261 [negative regulation of receptor-mediated endocytosis] GO:0048870 [cell motility] GO:0050690 [regulation of defense response to virus by virus] GO:0051022 [Rho GDP-dissociation inhibitor binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0051496 [positive regulation of stress fiber assembly] GO:0051668 [localization within membrane] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060263 [regulation of respiratory burst] GO:0070062 [extracellular exosome] GO:0071526 [semaphorin-plexin signaling pathway] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:0097190 [apoptotic signaling pathway] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
P63000 [Direct mapping] Ras-related C3 botulinum toxin substrate 1 A4D2P0 [Target identity:100%; Query identity:100%] Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e; cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA
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SCAMPI predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)