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Reliability

Reliability

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Method

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Specificity

Cell line

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Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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RAC1
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RAC1

Gene description

Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

Protein class

Cancer-related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, highly abundant in epithelial cells.

DATA RELIABILITY

Data reliability
description

Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

Approved based on 2 antibodies.
HPA047820 , CAB035994
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

RAC1 (HGNC Symbol)

Synonyms

p21-Rac1, Rac-1, TC-25

Description

Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

7

Cytoband

p22.1

Chromosome location (bp)

6374523 - 6403977

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136238 (version 83.38)

Entrez gene

5879

UniProt

P63000 (UniProt - Evidence at protein level)

neXtProt

NX_P63000

Antibodypedia

RAC1 antibodies

PROTEIN BROWSER

RAC1-001
RAC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAC1-001
ENSP00000258737
ENST00000348035
P63000 [Direct mapping]
Ras-related C3 botulinum toxin substrate 1
A4D2P1 [Target identity:100%; Query identity:100%]
Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_a; Ras-related C3 botulinum toxin substrate 1 isoform Rac1; cDNA FLJ30431 fis, clone BRACE2008968, highly similar to Ras-related C3 botulinum toxin substrate 1; cDNA FLJ75553, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008361 [regulation of cell size]
GO:0009611 [response to wounding]
GO:0009653 [anatomical structure morphogenesis]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030041 [actin filament polymerization]
GO:0030168 [platelet activation]
GO:0030334 [regulation of cell migration]
GO:0031295 [T cell costimulation]
GO:0031529 [ruffle organization]
GO:0031996 [thioesterase binding]
GO:0032707 [negative regulation of interleukin-23 production]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048870 [cell motility]
GO:0050690 [regulation of defense response to virus by virus]
GO:0051022 [Rho GDP-dissociation inhibitor binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051668 [localization within membrane]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060263 [regulation of respiratory burst]
GO:0070062 [extracellular exosome]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
192 aa
21.4 kDa
No 0
RAC1-002
ENSP00000348461
ENST00000356142
P63000 [Direct mapping]
Ras-related C3 botulinum toxin substrate 1
A4D2P0 [Target identity:100%; Query identity:100%]
Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e; cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001891 [phagocytic cup]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002093 [auditory receptor cell morphogenesis]
GO:0002551 [mast cell chemotaxis]
GO:0003382 [epithelial cell morphogenesis]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006911 [phagocytosis, engulfment]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006972 [hyperosmotic response]
GO:0007010 [cytoskeleton organization]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008361 [regulation of cell size]
GO:0009611 [response to wounding]
GO:0009653 [anatomical structure morphogenesis]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010762 [regulation of fibroblast migration]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0014041 [regulation of neuron maturation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016032 [viral process]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017137 [Rab GTPase binding]
GO:0019897 [extrinsic component of plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021831 [embryonic olfactory bulb interneuron precursor migration]
GO:0021894 [cerebral cortex GABAergic interneuron development]
GO:0022604 [regulation of cell morphogenesis]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030041 [actin filament polymerization]
GO:0030168 [platelet activation]
GO:0030334 [regulation of cell migration]
GO:0030742 [GTP-dependent protein binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031295 [T cell costimulation]
GO:0031410 [cytoplasmic vesicle]
GO:0031529 [ruffle organization]
GO:0031901 [early endosome membrane]
GO:0031996 [thioesterase binding]
GO:0032587 [ruffle membrane]
GO:0032707 [negative regulation of interleukin-23 production]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0042826 [histone deacetylase binding]
GO:0042995 [cell projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043652 [engulfment of apoptotic cell]
GO:0045087 [innate immune response]
GO:0045216 [cell-cell junction organization]
GO:0045453 [bone resorption]
GO:0045740 [positive regulation of DNA replication]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048532 [anatomical structure arrangement]
GO:0048813 [dendrite morphogenesis]
GO:0048870 [cell motility]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0050690 [regulation of defense response to virus by virus]
GO:0051022 [Rho GDP-dissociation inhibitor binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051668 [localization within membrane]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051932 [synaptic transmission, GABAergic]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060263 [regulation of respiratory burst]
GO:0070062 [extracellular exosome]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0071542 [dopaminergic neuron differentiation]
GO:0072659 [protein localization to plasma membrane]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090103 [cochlea morphogenesis]
GO:0097178 [ruffle assembly]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
Show all
211 aa
23.5 kDa
No 0

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