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PDPK1

GENERAL INFORMATION

Gene name

 PDPK1

Gene description

 3-phosphoinositide dependent protein kinase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035199 , CAB004272
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDPK1 (HGNC Symbol)

Synonyms

 PDK1

Description

 3-phosphoinositide dependent protein kinase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 2537964 - 2603188

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140992 (version 83.38)

Entrez gene

 5170

UniProt

 O15530 (UniProt - Evidence at protein level)

neXtProt

 NX_O15530

Antibodypedia

 PDPK1 antibodies

PROTEIN BROWSER
PDPK1-001
PDPK1-002
PDPK1-003
PDPK1-008
PDPK1-013
PDPK1-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDPK1-001
ENSP00000344220
ENST00000342085
O15530 [Direct mapping]
3-phosphoinositide-dependent protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003323 [type B pancreatic cell development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004676 [3-phosphoinositide-dependent protein kinase activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006972 [hyperosmotic response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010594 [regulation of endothelial cell migration]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0016004 [phospholipase activator activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016477 [cell migration]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030168 [platelet activation]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031295 [T cell costimulation]
GO:0032148 [activation of protein kinase B activity]
GO:0032869 [cellular response to insulin stimulus]
GO:0034122 [negative regulation of toll-like receptor signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042995 [cell projection]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043274 [phospholipase binding]
GO:0043304 [regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048041 [focal adhesion assembly]
GO:0050852 [T cell receptor signaling pathway]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097481 [neuronal postsynaptic density]
Show all
 556 aa
63.2 kDa 		No 0
PDPK1-002
ENSP00000268673
ENST00000268673
O15530 [Direct mapping]
3-phosphoinositide-dependent protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004676 [3-phosphoinositide-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016004 [phospholipase activator activity]
GO:0016477 [cell migration]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019722 [calcium-mediated signaling]
GO:0030036 [actin cytoskeleton organization]
GO:0030168 [platelet activation]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031295 [T cell costimulation]
GO:0032148 [activation of protein kinase B activity]
GO:0032869 [cellular response to insulin stimulus]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042995 [cell projection]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043274 [phospholipase binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097191 [extrinsic apoptotic signaling pathway]
Show all
 429 aa
48.2 kDa 		No 0
PDPK1-003
ENSP00000373876
ENST00000389224
E9PER6 [Direct mapping]
3-phosphoinositide-dependent protein kinase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 529 aa
60.3 kDa 		No 0
PDPK1-008
ENSP00000455551
ENST00000461815
H3BQ10 [Direct mapping]
3-phosphoinositide-dependent protein kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 149 aa
16.8 kDa 		No 0
PDPK1-013
ENSP00000395357
ENST00000441549
O15530 [Direct mapping]
3-phosphoinositide-dependent protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004676 [3-phosphoinositide-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010518 [positive regulation of phospholipase activity]
GO:0016004 [phospholipase activator activity]
GO:0016477 [cell migration]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019722 [calcium-mediated signaling]
GO:0030036 [actin cytoskeleton organization]
GO:0030168 [platelet activation]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031295 [T cell costimulation]
GO:0032148 [activation of protein kinase B activity]
GO:0032869 [cellular response to insulin stimulus]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042995 [cell projection]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043274 [phospholipase binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097191 [extrinsic apoptotic signaling pathway]
Show all
 454 aa
50.8 kDa 		No 0
PDPK1-015
ENSP00000455492
ENST00000566659
H3BPW1 [Direct mapping]
3-phosphoinositide-dependent protein kinase 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 88 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.