Cell atlas - LGSN - The Human Protein Atlas

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LGSN

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	LGSN
Gene description	Lengsin, lens protein with glutamine synthetase domain
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (A549, BEWO, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039983
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, BEWO, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039983	A549	Nucleoplasm
	HPA039983	A549	Vesicles
	HPA039983	CACO-2	Nucleoplasm
	HPA039983	CACO-2	Vesicles
	HPA039983	U-2 OS	Nucleoplasm
	HPA039983	U-2 OS	Vesicles

GENE INFORMATION
Gene name	LGSN (HGNC Symbol)
Synonyms	GLULD1, LGS
Description	Lengsin, lens protein with glutamine synthetase domain (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Chromosome	6
Cytoband	q12
Chromosome location (bp)	63275951 - 63319977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146166 (version 83.38)
Entrez gene	51557
UniProt	Q5TDP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TDP6
Antibodypedia	LGSN antibodies

PROTEIN BROWSER

LGSN-001	LGSN-002	LGSN-201	LGSN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGSN-001 ENSP00000359691 ENST00000370657	Q5TDP6 [Direct mapping] Lengsin Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006542 [glutamine biosynthetic process] GO:0006807 [nitrogen compound metabolic process] Show all	509 aa 57.3 kDa	No	0
LGSN-002 ENSP00000431246 ENST00000485906	A0A0A0MTD2 [Direct mapping] Lengsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0006542 [glutamine biosynthetic process] GO:0006807 [nitrogen compound metabolic process] Show all	191 aa 21.9 kDa	No	0
LGSN-201 ENSP00000359692 ENST00000370658	Q5TDP6 [Direct mapping] Lengsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0006542 [glutamine biosynthetic process] GO:0006807 [nitrogen compound metabolic process] Show all	208 aa 23.5 kDa	No	0
LGSN-202 ENSP00000479173 ENST00000622415	Q5TDP6 [Direct mapping] Lengsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0006542 [glutamine biosynthetic process] Show all	118 aa 13.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.