Expression of LGSN in cancer - Summary - The Human Protein Atlas

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LGSN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LGSN
Gene description	Lengsin, lens protein with glutamine synthetase domain
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (lung cancer)
HPA (cell line):	Cell line enhanced (A549, BEWO, CACO-2)
HPA (normal tissue):	Tissue enhanced (kidney, liver, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in lens.

ANTIBODY IHC RELIABILITY
Data reliability description	Limited external characterization data supports antibody staining but no internal RNA data available for correlation. Paired antibodies with high similarity supports the protein profile.
Reliability score	Supported based on 2 antibodies. HPA030957 , HPA039983
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (lung cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030957	HPA039983

GENE INFORMATION
Gene name	LGSN (HGNC Symbol)
Synonyms	GLULD1, LGS
Description	Lengsin, lens protein with glutamine synthetase domain (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Chromosome	6
Cytoband	q12
Chromosome location (bp)	63275951 - 63319977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146166 (version 83.38)
Entrez gene	51557
UniProt	Q5TDP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TDP6
Antibodypedia	LGSN antibodies

PROTEIN BROWSER

LGSN-001	LGSN-002	LGSN-201	LGSN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGSN-001 ENSP00000359691 ENST00000370657	Q5TDP6 [Direct mapping] Lengsin Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006542 [glutamine biosynthetic process] GO:0006807 [nitrogen compound metabolic process] Show all	509 aa 57.3 kDa	No	0
LGSN-002 ENSP00000431246 ENST00000485906	A0A0A0MTD2 [Direct mapping] Lengsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0006542 [glutamine biosynthetic process] GO:0006807 [nitrogen compound metabolic process] Show all	191 aa 21.9 kDa	No	0
LGSN-201 ENSP00000359692 ENST00000370658	Q5TDP6 [Direct mapping] Lengsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0006542 [glutamine biosynthetic process] GO:0006807 [nitrogen compound metabolic process] Show all	208 aa 23.5 kDa	No	0
LGSN-202 ENSP00000479173 ENST00000622415	Q5TDP6 [Direct mapping] Lengsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004356 [glutamate-ammonia ligase activity] GO:0006542 [glutamine biosynthetic process] Show all	118 aa 13.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.