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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

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Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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LGSN
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

LGSN

Gene description

Lengsin, lens protein with glutamine synthetase domain

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (kidney, liver, placenta)
GTEx:Tissue enhanced (liver)
FANTOM5:Not detected

Protein evidence

Evidence at protein level

Protein expression

Selective expression in lens.

DATA RELIABILITY

Data reliability
description

Limited external characterization data supports antibody staining but no internal RNA data available for correlation. Paired antibodies with high similarity supports the protein profile.

Reliability score

Supported based on 2 antibodies.
HPA030957 , HPA039983
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Eye
N/A
Eye
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Eye

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, liver, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

LGSN (HGNC Symbol)

Synonyms

GLULD1, LGS

Description

Lengsin, lens protein with glutamine synthetase domain (HGNC Symbol)

Entrez gene summary

This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Chromosome

6

Cytoband

q12

Chromosome location (bp)

63275951 - 63319977

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146166 (version 83.38)

Entrez gene

51557

UniProt

Q5TDP6 (UniProt - Evidence at protein level)

neXtProt

NX_Q5TDP6

Antibodypedia

LGSN antibodies

PROTEIN BROWSER

LGSN-001
LGSN-002
LGSN-201
LGSN-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LGSN-001
ENSP00000359691
ENST00000370657
Q5TDP6 [Direct mapping]
Lengsin
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004356 [glutamate-ammonia ligase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006542 [glutamine biosynthetic process]
GO:0006807 [nitrogen compound metabolic process]
Show all
509 aa
57.3 kDa
No 0
LGSN-002
ENSP00000431246
ENST00000485906
A0A0A0MTD2 [Direct mapping]
Lengsin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004356 [glutamate-ammonia ligase activity]
GO:0006542 [glutamine biosynthetic process]
GO:0006807 [nitrogen compound metabolic process]
Show all
191 aa
21.9 kDa
No 0
LGSN-201
ENSP00000359692
ENST00000370658
Q5TDP6 [Direct mapping]
Lengsin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004356 [glutamate-ammonia ligase activity]
GO:0006542 [glutamine biosynthetic process]
GO:0006807 [nitrogen compound metabolic process]
Show all
208 aa
23.5 kDa
No 0
LGSN-202
ENSP00000479173
ENST00000622415
Q5TDP6 [Direct mapping]
Lengsin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004356 [glutamate-ammonia ligase activity]
GO:0006542 [glutamine biosynthetic process]
Show all
118 aa
13.2 kDa
No 0

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