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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ITGA5
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ITGA5

Gene description

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

Protein class

Cancer-related genes
CD markers
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Selective membranous expression in smooth muscle and trophoblastic cells in placenta.

DATA RELIABILITY

Data reliability
description

Paired antibodies with high similarity supports the protein profile.

Reliability score

Supported based on 2 antibodies.
HPA002642 , CAB009008
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ITGA5 (HGNC Symbol)

Synonyms

CD49e, FNRA

Description

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

54395261 - 54419460

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161638 (version 83.38)

Entrez gene

3678

UniProt

P08648 (UniProt - Evidence at protein level)

neXtProt

NX_P08648

Antibodypedia

ITGA5 antibodies

PROTEIN BROWSER

ITGA5-001
ITGA5-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGA5-001
ENSP00000293379
ENST00000293379
P08648 [Direct mapping]
Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001618 [virus receptor activity]
GO:0001726 [ruffle]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007613 [memory]
GO:0008305 [integrin complex]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0030198 [extracellular matrix organization]
GO:0030335 [positive regulation of cell migration]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031410 [cytoplasmic vesicle]
GO:0031589 [cell-substrate adhesion]
GO:0032587 [ruffle membrane]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0035313 [wound healing, spreading of epidermal cells]
GO:0035987 [endodermal cell differentiation]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0045202 [synapse]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0071062 [alphav-beta3 integrin-vitronectin complex]
GO:2000811 [negative regulation of anoikis]
Show all
1049 aa
114.5 kDa
Yes 1
ITGA5-012
ENSP00000450267
ENST00000547197
H0YIV7 [Direct mapping]
Integrin alpha-5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
119 aa
13.2 kDa
No 1

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