Expression of SNRNP25 in cancer - Summary - The Human Protein Atlas

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SNRNP25

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SNRNP25
Gene description	Small nuclear ribonucleoprotein 25kDa (U11/U12)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA041183 , HPA044248
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA041183	HPA044248

GENE INFORMATION
Gene name	SNRNP25 (HGNC Symbol)
Synonyms	C16orf33
Description	Small nuclear ribonucleoprotein 25kDa (U11/U12) (HGNC Symbol)
Entrez gene summary	Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	53010 - 57669
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161981 (version 83.38)
Entrez gene	79622
UniProt	Q9BV90 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BV90
Antibodypedia	SNRNP25 antibodies

PROTEIN BROWSER

SNRNP25-001	SNRNP25-006	SNRNP25-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNRNP25-001 ENSP00000293861 ENST00000293861	Q4TT61 [Direct mapping] Chromosome 16 open reading frame 33; U11/U12 small nuclear ribonucleoprotein 25 kDa protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0045171 [intercellular bridge] Show all	123 aa 14.3 kDa	No	0
SNRNP25-006 ENSP00000391289 ENST00000417493	B8ZZ06 [Direct mapping] Chromosome 16 open reading frame 33; U11/U12 small nuclear ribonucleoprotein 25 kDa protein Show all	Predicted intracellular proteins Show all		96 aa 11.1 kDa	No	0
SNRNP25-201 ENSP00000372482 ENST00000383018	Q9BV90 [Direct mapping] U11/U12 small nuclear ribonucleoprotein 25 kDa protein Show all	Predicted intracellular proteins Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005689 [U12-type spliceosomal complex] GO:0005737 [cytoplasm] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0045171 [intercellular bridge] Show all	132 aa 15.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.