Expression of SFMBT1 in cancer - Summary

GENERAL INFORMATION
Gene name	SFMBT1
Gene description	Scm-like with four mbt domains 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Group enriched (parathyroid gland, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a majority of tissues, most abundant in gastrointestinal tract and testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA036152 , HPA036153
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036152	HPA036153

GENE INFORMATION
Gene name	SFMBT1 (HGNC Symbol)
Synonyms	DKFZp434L243, RU1, SFMBT
Description	Scm-like with four mbt domains 1 (HGNC Symbol)
Entrez gene summary	This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	52903572 - 53046750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163935 (version 83.38)
Entrez gene	51460
UniProt	Q9UHJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHJ3
Antibodypedia	SFMBT1 antibodies

PROTEIN BROWSER

SFMBT1-001	SFMBT1-004	SFMBT1-005	SFMBT1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFMBT1-001 ENSP00000378235 ENST00000394752	Q9UHJ3 [Direct mapping] Scm-like with four MBT domains protein 1 A0A024R338 [Target identity:100%; Query identity:100%] Scm-like with four mbt domains 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007283 [spermatogenesis] GO:0016568 [chromatin modification] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048635 [negative regulation of muscle organ development] Show all	866 aa 98.1 kDa	No	0
SFMBT1-004 ENSP00000418950 ENST00000483069	C9IZZ5 [Direct mapping] Scm-like with four MBT domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	94 aa 10.5 kDa	No	0
SFMBT1-005 ENSP00000418860 ENST00000482396	C9IY64 [Direct mapping] Scm-like with four MBT domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	121 aa 13.8 kDa	No	0
SFMBT1-008 ENSP00000419215 ENST00000497586	C9JWI3 [Direct mapping] Scm-like with four MBT domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.5 kDa	No	0