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LAT

GENERAL INFORMATION

Gene name

 LAT

Gene description

 Linker for activation of T cells

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in megakaryocytes and immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA011157 , CAB002223 , CAB012978
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 LAT (HGNC Symbol)

Synonyms

 LAT1

Description

 Linker for activation of T cells (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 28984826 - 28990783

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213658 (version 83.38)

Entrez gene

 27040

UniProt

 O43561 (UniProt - Evidence at protein level)

neXtProt

 NX_O43561

Antibodypedia

 LAT antibodies

PROTEIN BROWSER
LAT-001
LAT-002
LAT-004
LAT-005
LAT-007
LAT-011
LAT-012
LAT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LAT-001
ENSP00000354119
ENST00000360872
O43561 [Direct mapping]
Linker for activation of T-cells family member 1
A0A024QZD6 [Target identity:100%; Query identity:100%]
Linker for activation of T cells, isoform CRA_f
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001772 [immunological synapse]
GO:0002250 [adaptive immune response]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
Show all
 262 aa
27.9 kDa 		Yes 0
LAT-002
ENSP00000378845
ENST00000395461
O43561 [Direct mapping]
Linker for activation of T-cells family member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001772 [immunological synapse]
GO:0002250 [adaptive immune response]
GO:0002260 [lymphocyte homeostasis]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048872 [homeostasis of number of cells]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
Show all
 269 aa
28.6 kDa 		No 1
LAT-004
ENSP00000378841
ENST00000395456
O43561 [Direct mapping]
Linker for activation of T-cells family member 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001772 [immunological synapse]
GO:0002250 [adaptive immune response]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
Show all
 233 aa
25 kDa 		Yes 0
LAT-005
ENSP00000456761
ENST00000566177
O43561 [Direct mapping]
Linker for activation of T-cells family member 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001772 [immunological synapse]
GO:0002250 [adaptive immune response]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
Show all
 261 aa
27.8 kDa 		Yes 0
LAT-007
ENSP00000398793
ENST00000454369
O43561 [Direct mapping]
Linker for activation of T-cells family member 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001772 [immunological synapse]
GO:0002250 [adaptive immune response]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
Show all
 232 aa
24.8 kDa 		Yes 0
LAT-011
ENSP00000455728
ENST00000570232
H3BQD8 [Direct mapping]
Linker for activation of T-cells family member 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
GO:0016020 [membrane]
Show all
 166 aa
17.4 kDa 		No 0
LAT-012
ENSP00000457036
ENST00000564277
O43561 [Direct mapping]
Linker for activation of T-cells family member 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001772 [immunological synapse]
GO:0002250 [adaptive immune response]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050863 [regulation of T cell activation]
Show all
 232 aa
24.8 kDa 		Yes 0
LAT-201
ENSP00000488120
ENST00000630764
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
GO:0016020 [membrane]
Show all
 85 aa
9.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.