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PODXL

GENERAL INFORMATION

Gene name

 PODXL

Gene description

 Podocalyxin-like

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus and seminal vesicle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 6 antibodies.
HPA002110 , HPA045507 , CAB016169 , CAB062558 , CAB068219 , CAB068220
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PODXL (HGNC Symbol)

Synonyms

 Gp200, PC, PCLP

Description

 Podocalyxin-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q32.3

Chromosome location (bp)

 131500262 - 131558217

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128567 (version 83.38)

Entrez gene

 5420

UniProt

 O00592 (UniProt - Evidence at protein level)

neXtProt

 NX_O00592

Antibodypedia

 PODXL antibodies

PROTEIN BROWSER
PODXL-001
PODXL-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PODXL-001
ENSP00000319782
ENST00000322985
O00592 [Direct mapping]
Podocalyxin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0016324 [apical plasma membrane]
GO:0016477 [cell migration]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0031528 [microvillus membrane]
GO:0032534 [regulation of microvillus assembly]
GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin]
GO:0036057 [slit diaphragm]
GO:0045121 [membrane raft]
GO:0070062 [extracellular exosome]
GO:0072015 [glomerular visceral epithelial cell development]
GO:0072175 [epithelial tube formation]
Show all
 526 aa
55.4 kDa 		Yes 1
PODXL-005
ENSP00000367817
ENST00000378555
O00592 [Direct mapping]
Podocalyxin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0016324 [apical plasma membrane]
GO:0016477 [cell migration]
GO:0022407 [regulation of cell-cell adhesion]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030335 [positive regulation of cell migration]
GO:0031528 [microvillus membrane]
GO:0032534 [regulation of microvillus assembly]
GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin]
GO:0036057 [slit diaphragm]
GO:0044297 [cell body]
GO:0045121 [membrane raft]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0072015 [glomerular visceral epithelial cell development]
GO:0072175 [epithelial tube formation]
Show all
 558 aa
58.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.